Bone biology & skeletal homeostasis studies include:

• Osteoclasts, osteoblasts, and osteocytes in bone remodeling and mechanotransduction.
• Signaling mechanisms mediating effects of hormones, growth factors, and cytokines in bone cells.
• Bone matrix composition, structure, and function.
• Pre-clinical development of novel therapeutics for osteoporosis.

Clinical studies in osteoporosis and metabolic bone disorders include:

• Epidemiology, pathogenesis, and pathophysiology.
• Environmental and genetic risk factors.
• Treatment, prevention, and diagnosis.

Bone quality and skeletal imaging:

• In vivo methods for macro and micro scale imaging of bone.
• Architecture and mechanical properties of bone.
• Multi-scale modeling of the human bone.
• Assessment of bone quality.
• Clinical studies related to bone strength and density.