This program consists of several components: epidermal repair and regeneration, melanocyte biology, skin appendages, and vascular/lymphatics networks of the skin. Basic, translational, and clinical studies in these areas of research are supported by this program. Within each of these components, specific focus areas include:
Skin Repair and Regeneration:
- Basic studies of skin regeneration.
- Analysis of keratinocyte behavior during the normal wound healing process.
- New animal models of wound repair and regeneration.
- Basic, translational and clinical studies of chronic wounds.
- Abnormal wound healing in hereditary skin diseases.
- Skin scarring.
- Epithelial, mesenchymal and induced pluripotent stem cells in skin repair.
- Skin tissues engineering and improved skin equivalents.
- Normal melanocyte development, differentiation and homeostasis
- Skin pigmentation process and its regulation.
- Skin pigmentation disorders including hyperpigmentation and albinism.
- Photobiology of the skin.
- Melanocyte stem cells and their regulation.
- Early melanocyte transformation, melanocytic nevi, and melanoma prevention.
- Development and maintenance of skin appendages.
- Diseases of skin appendages including hair, nails, sweat and sebaceous glands.
- Identifying potential stem cells and their niches.
- Function and regulation of stem cells in normal skin and diseases.
- Regenerative potential and conditions of skin appendages.
Skin Vasculature and Lymphatic System:
- Mechanisms of skin blood vessels and angiogenesis and lymphangiogenesis.
- Structure-function of blood and lymphatic vessels in normal skin development.
- Cellular, molecular biology and genetics of skin vasculature and lymphatics.
- Skin vascular malformations such as hemangioma and port wine stain.